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Hepatotoxic effects of repeated administration of oriental hornet (vespa orientalis) venom

✍ Scribed by M. G. Neuman; M. Waron; E. Scapa; J. Eshchar; J. S. Ishay

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
237 KB
Volume
4
Category
Article
ISSN
0887-8013

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✦ Synopsis

Abstract

Venom sac extract (VSE) of the Oriental hornet (Vespa orientalis) has been shown to exert a toxic effect on hepatic cells. The present work set out to examine its effect on liver cells using serum levels of a lysosomal hydrolase as a marker of injury in rats. Serum activities of beta‐N‐acetyl hexosaminidase (BNAH; EC 3.2.1.30) were found to be positively correlated with the number of treatments received by the rats. The maximal elevation occurred from the third to the sixth day and comprised a 2‐3‐fold increase over the control mean level. This enhancement effect was reversible. The rat envenomend for 2 wk showed 3.5 times as much BNAH activity as in control rats. Biochemical analysis revealed increased specific activity of the lysosomal enzyme in rats treated repeatedly with VSE.

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