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Hepatotoxic effects elicited by n-hexane or n- heptane

✍ Scribed by Dr. S. K. Goel; G. S. Rao; K. P. Pandya

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 315 KB
Volume: 8
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550080203

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✦ Synopsis

Hepatotoxic effects of ti-hexane and n-heptane administered i.p. ( I ml/kg body wt) were studied in albino rats after 1, 2, 7 and 45 days of treatment. Hepatic protein content decreased with n-heptane and total sulphydryl content showed a significant decrease in the rats exposed to either solvent. A significant increase in lipid peroxidation was observed after 24 h and 48 h exposure to ti-hexane or ti-heptane. A marked decrease in drug metabolizing activity and an increase in pentabarbitone sleeping time was also observed. Hepatic glucose-6-phosphatase, a microsomal marker enzyme, showed a significant decrease. o16(L437xi'xx/o2uux 1 -03$05 .ou 0 19XX hy John Wiley & Sons, Ltd.

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