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Hepatosplenic γδ T-cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature

✍ Scribed by Philip R. Roelandt; Johan Maertens; Peter Vandenberghe; Chris Verslype; Tania Roskams; Raymond Aerts; Frederik Nevens; Daan Dierickx

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
358 KB
Volume
15
Category
Article
ISSN
1527-6465

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✦ Synopsis

Hepatosplenic ␥␦ T-cell lymphoma is a rare lymphoproliferative disorder originating from natural killer-like V␦1-lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation. Both patients had thrombocytopenia with (hepato)splenomegaly but without peripheral lymphadenopathies and sinusoidal infiltration of the liver and spleen by monomorphic ␥␦-lymphocytes on pathological examination. The clinical and pathological findings, immunophenotypical profile, prognosis, and treatment are highlighted. In order to make an early diagnosis, physicians who take care of liver transplant recipients should be aware of the characteristic features of this posttransplant lymphoproliferative disorder. Therefore, a diagnostic algorithm is proposed.

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