Hepatoprotective Effect of Some Edible Mushrooms

✍ Scribed by V. E. C. Ooi

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 247 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199609)10:6<536::aid-ptr893>3.0.co;2-y

✦ Synopsis

Seven locally available edible mushrooms were screened for their hepatoprotective activities using paracetamol (APAP)-induced liver injury in the rat as a model of chemical hepatitis. A single oral dose of 1.0 g/kg of APAP was able to produce significantly elevated levels of serum glutamic pyruvic transarmn ' ase (SGPT) and glutamic oxaloacetic transaminase (SGOT). Administraiton of 300 m&g of the extracts from Lentinus erodes, Grifoh frondosa and Tkicholoma lobayense could significantly reduce the APAP-induced acute elevation in the levels of SGPT and SGOT in rats. The mushroom crude drugs probably act to prevent the fall of hepatic reduced gluthanione (GSH) through some GSH-dependent enzymes and preserve the structural integrity of the cellular membrane of hepatocytes, or probably protect against paracetamol-induced liver injury through their antioxidant properties acting as a scavenger of free radicals even at low levels of GSH.