Hepatoprotective action of nine constituents isolated from the leaves of Clausena lansium in mice

✍ Scribed by Geng Tao Liu; Wei-Xun Li; Yan-Yong Chen; Huai-Ling Wei

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 387 KB
• Volume: 39
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/(sici)1098-2299(199610)39:2<174::aid-ddr10>3.0.co;2-c

✦ Synopsis

The hepatoprotective actions of nine compounds isolated from the leaves of Clausena lansiurn (Loor.) Skeels, Rutaceae were studied. The nine compounds at the dose of 250 mgikg, except demethylsecoclausenamide, significantl:, depressed the elevated serum transaminase in mice intoxicated with CCI4. Further study on the more abundant components, seco-clausenamide and clausenamide, demonstrated that both compounds decreased the hepatotoxicity of thioacetamide and acetaminophen in mice. Clausenamide was shown to significantly inhibit CC14-induced lipid peroxidation of liver microsomes and ''C-CC14 covalent binding to microsomal lipids. The results indicate that eight compounds isolated from Clausena lansiurn have hepatoprotective activity in mice. Drug Dev. Res. 39:l 74-1 78.