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Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione

✍ Scribed by Lorelle I. Berkeley; Jonathan F. Cohen; Daune L. Crankshaw; Frances N. Shirota; Herbert T. Nagasawa

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 56 KB
Volume: 17
Category: Article
ISSN: 1095-6670
DOI: 10.1002/jbt.10069

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✦ Synopsis

Abstract

L‐Cysteine‐glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen‐induced hepatotoxicity. Since the corresponding D‐cysteine‐glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated. © 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:95–97, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10069

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