Hepatocyte nuclear factor 1 alpha (HNF-1α) mutations in maturity-onset diabetes of the young
✍ Scribed by Sian Ellard
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 260 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1059-7794
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📜 SIMILAR VOLUMES
One form of maturity-onset diabetes of the young, Type 3 (MODY3), results from mutations in the gene coding for hepatocyte nuclear factor-1␣ (HNF-1␣), a transcription factor first described in the liver. MODY3 is characterized by a defective glucosestimulated insulin secretion. Earlier observations
Maturity onset diabetes of the young (MODY) is a heterogeneous subtype of type II diabetes mellitus. To date, five MODY genes have been identified. Mutations in the hepatocyte nuclear factor-1a (HNF-1a) gene are associated with MODY3. In the present work, we implemented the HNF-1a promoter region in