✦ LIBER ✦

Hepatocyte growth factor (HGF) in ovarian epithelial tumour fluids stimulates the migration of ovarian carcinoma cells

✍ Scribed by Heidi M. Sowter; Anthony N. Corps; Stephen K. Smith

Publisher: John Wiley and Sons
Year: 1999
Tongue: French
Weight: 180 KB
Volume: 83
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19991112)83:4<476::aid-ijc7>3.0.co;2-v

No coin nor oath required. For personal study only.

✦ Synopsis

Hepatocyte growth factor (HGF) is a pleiotropic growth factor implicated in the growth and spread of some epithelial tumours. The epithelial cells of a proportion of ovarian tumours, and some ovarian carcinoma cell lines, express high levels of the HGF receptor, c-Met. In this study, we show that ovarian ascitic fluid as well as benign and malignant ovarian cyst fluids contain significant levels of HGF. Ovarian cyst and ascitic fluid stimulated the migration of the ovarian carcinoma cell line, SK-OV-3, and this was greatly reduced by the addition of an HGF-neutralising antibody. Non-malignant peritoneal fluid contained low levels of HGF, and did not stimulate migration of the SK-OV-3 cells. Our results show that HGF is present in benign and malignant ovarian cyst and ascitic fluid, and that HGF in ovarian tumour fluid may be a major inducer of ovarian carcinoma cell migration.

📜 SIMILAR VOLUMES

Hepatocyte growth factor (HGF) stimulate

Hepatocyte growth factor (HGF) stimulates tumour invasiveness in papillary carcinoma of the thyroid

✍ Scarpino, Stefania; Stoppacciaro, Antonella; Colarossi, Cristina; Cancellario, F 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB 👁 1 views

The present study has investigated the functional role of the Met receptor in primary cultures of 20 papillary carcinomas and of normal thyroid cells obtained from the same patients. Normal and tumour cells grew as adherent cells, formed a confluent monolayer after 10-20 days, had epithelial morphol

Hepatocyte growth factor stimulates moti

Hepatocyte growth factor stimulates motility, chemotaxis and mitogenesis in ovarian carcinoma cells expressing high levels of c-MET

✍ Anthony N. Corps; Heidi M. Sowter; Stephen K. Smith 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 150 KB 👁 1 views

A proportion of ovarian carcinomas markedly overexpress the proto-oncogene c-met, which encodes the receptor for hepatocyte growth factor (HGF). HGF may either stimulate or inhibit the multiplication of its target cells, and may also promote motogenesis and morphogenesis. In this study, we establish

Hepatocyte Growth Factor Induces Invasio

Hepatocyte Growth Factor Induces Invasion and Migration of Ovarian Cancer Cells by Decreasing the Expression of E-cadherin, β-catenin, and Caveolin-1

✍ Jun Hu; Shujuan Shao; Yang Song; Jinyao Zhao; Yan Dong; Linlin Gong; Peiman Yang 📂 Article 📅 2010 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 271 KB 👁 1 views

Stable amino-acid sequence of the Mannos

Stable amino-acid sequence of the Mannose-6-phosphate/insulin-like growth-factor-II receptor in ovarian carcinomas with loss of heterozygosity and in breast-cancer cell lines

✍ Jean-Marc Rey; Charles Theillet; Jean-Paul Brouillet; Henri Rochefort 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 143 KB 👁 2 views

The mannose-6-phosphate/insulin-like growth factor 2 receptor (Man-6-P/IGFII receptor) is involved in lysosomal enzyme sorting, IGFII degradation and pro-TGFbeta activation. Genetic alterations in hepatocarcinomas and a few breast cancers suggest that this receptor behaves as a tumor suppressor. Mor