Hepatocyte cell density regulates a minimal human and rat epidermal growth factor transcriptional regulatory region

Effect of cell density and epidermal gro

Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture

✍ J Greuet; L Pichard; J C Ourlin; C Bonfils; J Domergue; P Le Treut; P Maurel 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 411 KB 👁 2 views

The influence of cell density and epidermal growth factor (EGF) on the expression and inducibility of cytochrome P450 (CYP) genes of the CYP3A and CYP1A families in adult human hepatocytes in primary culture has been evaluated. Only when cultured at subconfluence and in the presence of EGF did hepat