Analyses of hepatocellular proliferation
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David A. Rudnick; Yunjun Liao; Jae-Koo An; Louis J. Muglia; David H. Perlmutter;
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Article
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2004
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John Wiley and Sons
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English
β 294 KB
β£-1-Antitrypsin (β£1-AT) deficiency is the most common cause of metabolic pediatric liver disease. Hepatocellular injury is caused by toxicity of the mutant β£-1-antitrypsin Z (β£1-ATZ) molecule retained within hepatocytes. In these studies, we used the PiZ transgenic mouse model of β£1-AT deficiency to