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Hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency

✍ Scribed by Rudnick, David; An, Jae-Koo; Muglia, Louis; Perlmutter, David; Teckman, Jeffrey


Book ID
122794271
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
248 KB
Volume
124
Category
Article
ISSN
0016-5085

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␣-1-Antitrypsin (␣1-AT) deficiency is the most common cause of metabolic pediatric liver disease. Hepatocellular injury is caused by toxicity of the mutant ␣-1-antitrypsin Z (␣1-ATZ) molecule retained within hepatocytes. In these studies, we used the PiZ transgenic mouse model of ␣1-AT deficiency to

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