Hepatocellular carcinoma: Is there a potential for chemoprevention using cyclooxygenase-2 inhibitors?

✍ Scribed by Hironori Koga

• Book ID: 102103581
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 181 KB
• Volume: 98
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/cncr.11576

✦ Synopsis

Abstract

Inhibitors of cyclooxygenase‐2 (COX‐2) have proapoptotic and antiangiogenic effects on malignant tumors and inhibit their invasion to surrounding tissues. These properties are derived from COX‐dependent and/or COX‐independent signaling via peroxisome proliferator‐activated receptor γ. Although the role of COX‐2 involvement in human hepatocarcinogenesis has not been determined yet, selective COX‐2 inhibitors with COX‐independent properties may potentially suppress hepatocarcinogenesis. This hypothesis should be confirmed in in vivo studies using animal models. These studies may provide insights into any application of the COX‐2 inhibitor for primary and/or secondary chemoprevention. Cancer 2003;98:661–7. © 2003 American Cancer Society.

DOI 10.1002/cncr.11576