## Abstract ## Background Hydrodynamic injection of naked plasmid DNA (pDNA) via the tail vein is a safe and effective method of gene transfer to the liver. However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and effi
✦ LIBER ✦
Hepatocellular carcinoma is induced by a subnecrogenic dose of diethylnitrosamine in previously fasted‐refed rats
✍ Scribed by Tessitore, Luciana
- Book ID
- 121704510
- Publisher
- Lawrence Erlbaum Associates, Inc.
- Year
- 1998
- Tongue
- English
- Weight
- 468 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0163-5581
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## Abstract To clarify the sequential changes in pRB and __p16__ during different stages of hepatocarcinogenesis such as fibrosis, cirrhosis, hepatocellular adenoma (HCA), and hepatocellular carcinoma (HCC), male Fischer 344 rats were singly injected with diethylnitrosamine (DEN), immediately follo