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Hepatocellular Carcinoma Induction in LEC Rats by a Low Dose of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline

✍ Scribed by Sone, Hideko ;Wakabayashi, Keiji ;Kushida, Hiromi ;Enomoto, Katsuhiko ;Mori, Michio ;Takeichi, Noritoshi ;Tsuda, Hiroyuki ;Sugimura, Takashi ;Nagao, Minako

Book ID: 108581149
Publisher: Wiley (Blackwell Publishing)
Year: 1996
Tongue: English
Weight: 376 KB
Volume: 87
Category: Article
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1996.tb00195.x

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## Abstract 2‐Amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ) and 2‐amino‐3,8‐dimethylimidazo[4,5‐__f__]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active