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Hepatocellular Carcinoma in Women: Probable Lack of Etiologic Association with Oral Contraceptive Steroids

✍ Scribed by Zachary D. Goodman; Kamal G. Ishak

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 611 KB
Volume: 2
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840020408

No coin nor oath required. For personal study only.

✦ Synopsis

To investigate the possibility of an association between oral contraceptive steroids (CS) and hepatocellular carcinoma (HCC), we reviewed 128 cases of HCC in women collected between 1953 and 1980. There were 48 cases under the age of 40, and 13 of these (27%) had used CS. However, 62% of HCC associated with CS and 58% of HCC in women under 40 not using CS were classified histologically as "fibrolamellar" carcinoma. This subtype of HCC occurs predominantly in young people, both male and female. The apparent increase in HCC in young women can be explained by the presence of cases of fibrolamellar carcinoma in this age group, an the apparent association with CS is probably coincidental.

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