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Hepatocellular carcinoma in a young woman with prolonged exposure to oral contraceptives

✍ Scribed by Gattanell, Perry N. ;Perloff, Marjorie ;Holland, James F.

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 989 KB
Volume: 4
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950040203

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✦ Synopsis

A case of hepatocellular carcinoma in a young female is presented in which the apparent etiology was the use of oral contraceptives for 5 1/2 years. Sequential therapeutic trials with intraarterial 5-fluorouracil, intraarterial adriamycin, and intravenous 1,3 bis[2-chloroethyl]-1-nitrosourea (BCNU) were unsuccesful. The adverse effects of oral contraceptives on the structure and function of hepatic tissue are reviewed.

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