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✦   LIBER   ✦

Hepatoblastoma: Assessment of criteria for histologic classification

✍ Scribed by Rowland, Jon M.

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
76 KB
Volume
39
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Background

Comparison of outcomes in different clinicopathologic studies of hepatoblastoma requires reproducible histologic classification. This review examines the diagnostic criteria employed by different pathologists for the classification of subtypes of hepatoblastoma and identifies specific problem areas.

Procedure

A selected review of published literature is provided.

Results

Published studies demonstrate that uniform criteria have not been applied in the classification of hepatoblastoma. These discrepancies hinder attempts to compare outcome data from different studies. Sampling error and potential treatment effects further complicate analysis of the published literature on the relationship between morphologic classification and outcome.

Conclusions

Standardized criteria are essential to allow reproducible histologic classification of hepatoblastoma. There is significant variation in diagnostic criteria used to define the major subtypes of hepatoblastoma in published studies. Additional potential problems are identified in sampling methods and treatment effects. Med Pediatr Oncol 2002;39:478–483. Β© 2002 Wiley‐Liss, Inc.

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