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Hepatobiliary disposition of valproic acid and valproate glucuronide: Use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions

โœ Scribed by CL Booth; GM Pollack; KL Brouwer

Book ID
118686209
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
276 KB
Volume
23
Category
Article
ISSN
0270-9139

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Hepatobiliary disposition of valproic ac
Hepatobiliary disposition of valproic acid and valproate glucuronide: Use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions
โœ C L Booth; G M Pollack; K L Brouwer ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 271 KB

with phenobarbital-associated impairment of canalicu-Previous work in this laboratory has suggested that lar egress of some organic anions. This work further supthe nonlinear disposition of valproic acid (VPA) in the ports the utility of pharmacokinetic modeling in: (1) derat may be due to nonlinear