Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

Contribution of the murine mdr1a P-glyco

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption

✍ Johan W. Smit; Alfred H. Schinkel; Michael Müller; Betty Weert; Dirk K. F. Meije 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB

In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta