✦ LIBER ✦

Hepatitis virus infection in an isolated canadian inuit (Eskimo) population

✍ Scribed by Dr. Gerald Y. Minuk; Lindsay E. Nicolle; Brian Postl; Jeanne G. Waggoner; Jay H. Hoofnagle

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 568 KB
Volume: 10
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890100405

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The epidemiology of Hepatitis A virus (HAV) and hepatitis B virus (HBV) infection was studied in a northern Canadian Inuit (Eskimo) settlement. Sera from 720 of the 850 inhabitants of Baker Lake, Canada, were tested for markers of HAV and HBV infection. Anti‐HAV was present in 71% of the residents and its prevalence increased with age. Serologic evidence of HBV infections was found in 27% of residents. The prevalence increased with age, being uncommon under the age of 20 (6%)and almost universal over the age of 60 (93%). Among the 29 hepatitis B surface antigen (HBsAg) carriers identified, all were adults, all had low levels of HBsAg, and all were negative for hepatitis B e antigen (HBeAg) and DNA polymerase but positive for antibody to HBeAg. These data demonstrate a high prevalence of HAV and HBV infection in this population. Further, they suggest that a dramatic decrease in the transmission of HRV infection has occurred over the past 20–30 years.

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