Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
β Scribed by Sun-Lung Tsai; Young-Mao Chen; Ming-Huei Chen; Chao-Yuan Huang; I-Shyan Sheen; Chau-Ting Yeh; Jyh-Hsiung Huang; George C. Kuo; Yun-Fan Liaw
- Book ID
- 118520221
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 363 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0016-5085
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Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes (CTL) have been shown to play a role in host defense and pathogenesis of chronic HCV infection. Our aim was to test the hypothesis that intrahepatic HCV-specific CTL activity may impact subsequent response to interferon alfa (IFN-β£) therapy. O
## Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope An epitope that acted as a weak agonist in the cytotoxicity assay was identified as part of the capsid protein of a hepatitis C virus (HCV) variant. In a low concentration,