Hepatitis C virus type I(1a) in Northern China

✍ Scribed by Junqi Niu; Umesh Kumar; Yu Pan; Yuanyuan Liu; Qingquan Zhan; Howard Thomas; Dr. John Monjardino

• Book ID: 102379282
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 407 KB
• Volume: 46
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890460113

✦ Synopsis

Twenty-four patients with hepatitis C virus (HCV) antibody from the Chinese North Western province of Jilin were further analysed by the immunoblot assay-2 (RIBA-2). reverse transcriptionpolymerase chain reaction (RT-PCR) for serum HCV RNA detection, and direct sequence-genotyping. Good concordance was found between the original second generation HCV antibody ELISA, RIBA-2, and serum HCV RNA. The occurrence of genotype I (la), a genotype not previously reported in China, is described in 5(20.8%) of 24 cases, in association with genotypes Il(1 b) and lIl(2a) which were found in 16(66.7%) and 3(12.5%) of 24 cases, respectively. Imported blood products were unlikely to be the source of infection with genotype I ( l a ) but could not be definitively ruled out.