A High-Throughput Radiometric Assay for
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Mauro Cerretani; Laura Di Renzo; Sergio Serafini; Alessandra Vitelli; Nadia Genn
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Article
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1999
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Elsevier Science
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English
β 127 KB
A novel radiometric in vitro assay for discovery of inhibitors of hepatitis C viral protease activity, suitable for high-throughput screening, was developed. The NS3 protein of hepatitis C virus (HCV) contains a serine protease, whose function is to process the majority of the nonstructural proteins