Since the natural history of hepatitis C virusassociated liver disease and the therapeutic responsiveness might vary according to liver and blood mononuclear cells viral levels, it may be important to quantitate viral RNA in liver, blood mononuclear cells and serum, and to compare these data with ge
Hepatitis C virus productive infection in mononuclear cells from patients with cryoglobulinaemia
β Scribed by D. Sansonno; F. A. Tucci; G. Lauletta; V. De Re; M. Montrone; L. Troiani; L. Sansonno; F. Dammacco
- Book ID
- 108699518
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 242 KB
- Volume
- 147
- Category
- Article
- ISSN
- 0009-9104
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## Abstract The mechanisms underlying chronicity of hepatitis C virus (HCV) infection are poorly understood, but the importance of impaired viral clearance by the immune system has been suggested. The prevalence of HCV infection of peripheral blood mononuclear cells (PBMC) was in investigated in 34
Sera from 103 patients were tested for hepatitis C virus RNA by nested polymerase chain reaction assay. Using primers from the highly conserved 5'-untranslated region, we detected hepatitis C virus RNA in 67 (88.2%) of 76 patients positive for antibody to hepatitis C virus by both second-generation