Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical response

Mutations in the NS5A region do not pred

Mutations in the NS5A region do not predict interferon-responsiveness in American patients infected with genotype 1b hepatitis C virus

✍ Chung, Raymond T.; Monto, Alexander; Dienstag, Jules L.; Kaplan, Lee M. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB 👁 2 views

A striking association has been demonstrated recently between mutations in amino acid residues 2209-2248 of the nonstructural protein 5a (NS5a) region of hepatitis C virus (HCV) and sustained responses to interferon in Japanese patients infected with genotype 1b. Therefore, analysis of this sequence