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Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1

✍ Scribed by Zhonghua Xiang; Ling Qiao; Yan Zhou; Lorne A. Babiuk; Qiang Liu

Book ID
116300991
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
424 KB
Volume
402
Category
Article
ISSN
0006-291X

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## Abstract AMP‐activated protein kinase (AMPK) is an intracellular fuel sensor that plays a key role in regulating fatty acid synthesis in liver. Sterol regulatory element‐binding protein (SREBP)‐1c is a master regulator of hepatic lipogenic gene expression. It has long been documented that AMPK a