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Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture

✍ Scribed by Ralf Bartenschlager; Sandra Sparacio

Book ID
116967886
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
870 KB
Volume
127
Category
Article
ISSN
0168-1702

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## Abstract Clinical isolates of hepatitis A virus (HAV) replicate inefficiently in cell culture unless mutations are acquired throughout the genome. An Ala‐to‐Val substitution in the nonstructural protein 2B (2B‐216) was known to have a major impact on replication in cell culture. Analysis of chim