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Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A

✍ Scribed by Francois H.T. Duong; Magdalena Filipowicz; Marco Tripodi; Nicola La Monica; Markus H. Heim

Book ID
119757447
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
620 KB
Volume
126
Category
Article
ISSN
0016-5085

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Numerous anti-hepatitis C virus (HCV) drugs targeting either the viral nonstructural 3 (NS3) protease or NS5B polymerase are currently in clinical testing. However, rapid resistance development is a major problem and optimal therapy will clearly require a combination of multiple mechanisms of action