Hepatitis C virus infection, Sjögren's syndrome, and non-Hodgkin's lymphoma
✍ Scribed by Albert Selva-O'Callaghan; Dolores Rodriguez-Pardo; Lluis Sanchez-Sitjes; Laia Matas-Pericas; Roser Solans-Laque; Josep Angel Bosch-Gil; Miguel Vilardell-Tarrés
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 86 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To characterize the clinical and immunologic patterns of expression, response to therapy, and outcome of patients with Sjögren's syndrome (SS) and associated hepatitis C virus (HCV) infection who developed B cell lymphoma. ## Methods Various international reference cente
Hepatitis C virus (HCV) has been suggested to play an etiological role in the development of B-cell non-Hodgkin's lymphoma (NHL) in Italy. However, another study in Scotland questioned increased risk of development of NHL in patients with chronic HCV infection. A total of 2,162 patients admitted to
Sjögren's syndrome (SS) represents a pathological model of the evolution from polyclonal B lymphocyte activation to oligoclonal/monoclonal B cell expansion, which may culminate in the development of a malignant lymphoproliferative disease. The different phases of this process are usually marked by t