Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL
โ Scribed by M. Matsushita; M. Hijikata; Y. Ohta; K. Iwata; M. Matsumoto; K. Nakao; K. Kanai; N. Yoshida; K. Baba; S. Mishiro
- Publisher
- Springer Vienna
- Year
- 1998
- Tongue
- English
- Weight
- 187 KB
- Volume
- 143
- Category
- Article
- ISSN
- 1432-8798
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Mannose-binding lectin (MBL) plays an important role in immune defense. We examined the MBL gene mutations and MBL levels in Chinese hepatitis B and hepatitis C patients with and without symptomatic cirrhosis. We recruited 190 hepatitis B and C patients, and 117 normal Chinese as controls. Serum MBL
## An association has been reported between mutations in the amino acid residues 2209-2248 of the nonstructural protein 5A (NS5A) gene (interferon-sensitivity determining region [ISDR]) and interferon efficacy in hepatitis C virus (HCV)-1b infection. This relationship was analyzed in chronic HCV-2