Only half of patients with chronic hepatitis C virus (HCV) infection and genotype-1 show a sustained antiviral response to the current antiviral therapy. The reason this treatment fails is unclear, and no reliable marker exists that predicts the treatment outcome. In the present study, we investigat
Hepatitis C virus infection and antiviral treatment
โ Scribed by Omata, Masao ;Yokosuka, Osamu ;Hosoda, Kazuhiko ;Kato, Naoya ;Ito, Yoshimi ;Ohto, Masao
- Book ID
- 105605408
- Publisher
- Springer-Verlag
- Year
- 1991
- Tongue
- English
- Weight
- 351 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0435-1339
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Fourteen chimpanzees were inoculated with pre- and posttreatment sera from seven patients with persistent hepatitis B virus infection and chronic hepatitis who had permanent responses of their infection to treatment with interferon and/or adenine arabinoside. Inoculation of pretreatment serum at a d
Twelve of 32 patients lost HBeAg and DNA polymerase from their serum after completing antiviral therapy with interferon and/or adenine arabinoside. Three lost serum HBsAg as well. Loss of corresponding viral markers from hepatic tissue was also seen. There was improvement in symptoms, hepatic tests,
The viral genotype may influence the response to interferon sion and more efficient antiviral immune response, is still (IFN) treatment in chronic hepatitis C virus (HCV) infection. unclear. To characterize potential mechanisms responsible for this ef-Several factors including viral load, disease se
Combination treatment with pegylated-interferon-alpha (PEG IFN-โฃ) and ribavirin, the current recommended therapy for chronic hepatitis C virus (HCV) infection, results in a sustained virological response (SVR) in only about half of patients. Because genes involved in the interferon-alpha pathway may
In hepatitis C virus (HCV) genotypes 2 and 3 patients, the high rate of relapse after 12 to 16 weeks of antiviral therapy is the main concern for shortening treatment duration. This study was undertaken to delineate predictors of relapse after short treatment in patients with undetectable HCV RNA at