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Hepatitis C virus genotypes implicated in mixed cryoglobulinemia

✍ Scribed by Nguyen, Quang Tri; Leruez-Ville, Marianne; Ferrière, Françoise; Cohen, Pascal; Roulot-Marullo, Dominique; Coste, Thierry; Dény, Paul; Guillevin, Loïc

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
59 KB
Volume
54
Category
Article
ISSN
0146-6615

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✦ Synopsis

Recent reports suggest that hepatitis C virus (HCV) might be a causative agent of mixed cryoglobulinemia. To determine whether the HCV genotype is a factor implicated in the onset of cryoglobulinemia, genotyping by direct sequencing of polymerase chain reaction products of the 5Ј non coding region was carried out among 45 HCV-infected patients. Genotypes 1 and 2 were found more prevalent in symptomatic cryoglobulinemia patients. Due to the presence of genotypes 4 and 5 found in this panel of French patients (9.3%), HCV genotyping based on sequence determination is recommended.

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