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Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

✍ Scribed by Wenyu Lin; Won Hyeok Choe; Yoichi Hiasa; Yoshitaka Kamegaya; Jason T. Blackard; Emmett V. Schmidt; Raymond T. Chung

Book ID
119758397
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
366 KB
Volume
128
Category
Article
ISSN
0016-5085

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## Abstract IFN‐α combined with ribavirin is used for the treatment of chronic hepatitis C. However, HCV has mechanisms to resist the antiviral actions of IFN‐α. In order to study the molecular mechanisms of this resistance, the effect of __HCV__ gene expression on IFN‐induced nuclear import of STA