Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies
β Scribed by Zania Stamataki; Stephen Coates; Matthew J. Evans; Mark Wininger; Kevin Crawford; Christine Dong; Yiu-lian Fong; David Chien; Sergio Abrignani; Peter Balfe; Charles M. Rice; Jane A. McKeating; Michael Houghton
- Book ID
- 116960048
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 697 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0264-410X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The genotype of hepatitis C virus (HCV) can profoundly affect the success of antiviral therapy for HCV infection. A possible contributing factor is a varied immune response elicited by infection with different HCV genotypes. In this study, fullβlength E2 proteins of HCV genotypes 1a, 1b
The isolation and characterization of human monoclonal antibodies (humAbs) against the hepatitis C Virus (HCV) glycoproteins E1 and E2 are described. B-cells from blood donors with anti-HCV were transformed with Epstein-Barr virus. The supernatants of the resulting lymphoblastoid clones were screene
The significance of circulating antibody to hepatitis C HCV E1 corresponds to the pestiviral gp33/gp25 envevirus (HCV) envelope glycoprotein 2 (E2)/nonstructural lope glycoprotein and the flaviviral envelope protein protein 1 (NS1) glycoprotein was studied in 83 patients (M/E), whereas E2/NS1 corres