𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia-related syndrome

✍ Scribed by M. Willems; L. Sheng; T. Roskams; B. Ramdani; J. M. Doutrelepont; F. Nevens; P. Durez; S. Treille; M. Adler; V. Desmet; J. Fevery; Prof. Dr. S. H. Yap

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
664 KB
Volume
44
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Recently, evidence has been presented for a possible association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients.

Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively.

These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manifestations of EMC. © 1994 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Hepatitis B virus subtypes and hepatitis
Hepatitis B virus subtypes and hepatitis C virus genotypes in patients with chronic liver disease or on maintenance hemodialysis in Indonesia
✍ Soeliadi Hadiwandowo; Fumio Tsuda; Hiroaki Okamoto; Hajime Tokita; Yu Wang; Take 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 549 KB

## Abstract Hepatitis B surface antigen (HBsAg) and hepatitis C virus (HCV) RNA were surveyed in patients in Yogyakarta, Indonesia, and their subtypes and genotypes were determined by serological methods and polymerase chain reaction with type‐specific primers, respectively. Of 149 patients with ch

Virological outcomes in patients infecte
Virological outcomes in patients infected chronically with hepatitis B virus genotype A in comparison with genotypes B and C
✍ Mariko Kobayashi; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 259 KB 👁 1 views

## Abstract In a single hospital in Tokyo, the 87 patients infected persistently with hepatitis B virus (HBV) genotype A, the 413 with B, and the 3,389 with C were compared for virological outcome. Hepatitis B surface antigen (HBsAg) was cleared from the serum in 12% (3/26), 2% (2/112), and 3% (23/

Analysis of the complete hepatitis B vir
Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis in relation to HBeAg and anti-HBe
✍ KaiYu Zhang; Fumio Imazeki; Kenichi Fukai; Makoto Arai; Tatsuo Kanda; Rintaro Mi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB 👁 2 views

## Abstract To investigate the relationship between viral factors and the development of chronic hepatitis B, the entire hepatitis B virus (HBV) genome of chronic carriers at different disease stages were analyzed. Eighty genotype C HBV carriers including 12 hepatitis B e antigen (HBeAg) positive a

Phase 1b study of pegylated interferon l
Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection
✍ Andrew J. Muir; Mitchell L. Shiffman; Atif Zaman; Boris Yoffe; Andrew de la Torr 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 678 KB

Interferon lambda 1 (IFN-k1) is a type III IFN that produces intracellular responses similar to those of IFN-a but in fewer cell types because of differences in the receptor distribution pattern, and this could potentially result in an improved safety profile. This was an open-label three-part study

Hepatitis C Virus p7 membrane protein qu
Hepatitis C Virus p7 membrane protein quasispecies variability in chronically infected patients treated with interferon and ribavirin, with or without amantadine
✍ S. Castelain; D. Bonte; F. Penin; C. François; D. Capron; S. Dedeurwaerder; P. Z 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 415 KB 👁 2 views

## Abstract A clinical study was carried out to compare the response rate of two groups of non‐responder (NR) hepatitis C virus (HCV) genotype 1 chronically infected patients treated with interferon and ribavirin, with or without amantadine. The viral load decreased more markedly in the group treat

Production of interleukin-18 and interle
Production of interleukin-18 and interleukin-12 in patients suffering from chronic hepatitis C virus infection before antiviral therapy
✍ E. Schvoerer; M.C. Navas; C. Thumann; A. Fuchs; N. Meyer; F. Habersetzer; F. Sto 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB

## Abstract Interleukin‐12 and ‐18 (IL‐12 and IL‐18) are known to enhance the cytotoxic T‐lymphocyte response synergistically, but their precise involvement in hepatitis C virus (HCV) infection is not well known, especially for IL‐18. Enzyme‐linked immunosorbent assay (ELISA) was used to study the