Hepatitis C virus and interferon type III (interferon-λ3/interleukin-28B and interferon-λ4): genetic basis of susceptibility to infection and response to antiviral treatment
✍ Scribed by Riva, E.; Scagnolari, C.; Turriziani, O.; Antonelli, G.
- Book ID
- 126556054
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 240 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1198-743X
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Amino acid (aa) substitutions of core 70 and 91 and in the NS5A (nonstructural protein 5A) interferon sensitivity determining region (ISDR) as well as genetic polymorphisms in the host interleukin-28B (IL28B) locus affect the outcome of interferon (IFN)-based therapies for patients with chronic hepa
## Abstract Interferon‐α (IFN‐α) has been used to treat hepatitis C Virus (HCV)‐induced infection but has been effective in only about half of all patients. It is suggested that the different responses to IFN‐α treatment in HCV infection may be influenced by HCV genotypes, HCV RNA titer at the begi