Hepatitis C Viral Kinetics in the Era of Direct Acting Antiviral Agents and Interleukin-28B
β Scribed by Harel Dahari; Jeremie Guedj; Alan S. Perelson; Thomas J. Layden
- Book ID
- 107540576
- Publisher
- Current Science Inc.
- Year
- 2011
- Tongue
- English
- Weight
- 356 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1540-3416
No coin nor oath required. For personal study only.
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Up to 30% of liver transplants will develop graft cirrhosis within 5 years after liver transplantation (LT) due to recurrent HCV-infection forwarding accelerated graft damage. Genetic variants of cytokines involved in the immune response may contribute to the degree of graft inflammation, fibrosis p
Genetic variation near the IL28B gene and substitution of amino acid (aa) 70 and 91 in the core region of hepatitis C virus (HCV) genotype 1b can predict the response to pegylated interferon (PEG-IFN)/ribavirin combination therapy, but its impact on triple therapy of telaprevir/PEG-IFN/ribavirin is