Hepatitis C infection is not associated with systemic HIV-associated non-hodgkin's lymphoma: A cohort study

✍ Scribed by Laura Waters; Justin Stebbing; Sundhiya Mandalia; Anne Marie Young; Mark Nelson; Brian Gazzard; Mark Bower

• Book ID: 102271604
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: French
• Weight: 67 KB
• Volume: 116
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.20988

✦ Synopsis

Abstract

Immunosuppression induced by the human immunodeficiency virus (HIV) increases the risk of developing non‐Hodgkin's lymphoma (NHL). As the hepatitis C virus (HCV) has been implicated in the development of B cell lymphomas, we compared the incidence of systemic NHL during HIV infection compared to HIV and HCV co‐infection. Of 5,832 individuals studied during the era of highly active anti‐retroviral therapy (HAART), 102 patients were diagnosed with systemic NHL. The incidence of systemic NHL was 6.9 of 10^4^ patient years during HIV infection compared to 7.1 of 10^4^ patient years during HIV alone (p = 0.9). In this immunocompromised patient population, there was no association between HCV infection and an increased risk of lymphoma. © 2005 Wiley‐Liss, Inc.