Hepatitis B Virus Replication in Damaged Endothelial Tissues of Patients with Extrahepatic Disease
β Scribed by Mason, Andrew; Theal, Jeremy; Bain, Vince; Adams, Elizabeth; Perrillo, Robert
- Book ID
- 121191007
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 230 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0002-9270
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Recent studies have demonstrated the presence of hepadnavirus-related nucleic acids in extrahepatic tissues in various animal models. The prevalence and biological significance of extrahepatic infection in humans remains undetermined. To characterize the tissue distribution and physical state of ext
## Abstract The presence of hepatitis B virus (HBV) DNA in extrahepatic tissues has been well documented. Whether HBV DNA can persist in extrahepatic tissues for long periods of time in the absence of replication in the liver has not been determined previously. Recently, two patients with endβstage