Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma
β Scribed by Dejean, Anne; Bougueleret, Lydie; Grzeschik, Karl-Heinz; Tiollais, Pierre
- Book ID
- 109744176
- Publisher
- Nature Publishing Group
- Year
- 1986
- Tongue
- English
- Weight
- 359 KB
- Volume
- 322
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/322070a0
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## Abstract The DNA of tumor tissue K1 obtained at autopsy from a case of hepatocellular carcinoma (HCC) in a 9βyearβold boy contained integrated hepatitis B virus (HBV) DNA at a single site in the chromosome (case 2, Chang et al.: Hepatology 13:316β320, 1991). To characterize further the integrate
By digestion with Hindlll restriction enzyme, a human hepatocellular carcinoma was shown to contain only 2 hepatitis B virus (HBV) DNA inserts. Both Hindlll fragments (8 and 16 kb) were molecularly cloned and the structures of HBV DNA and adjacent host sequences were analyzed. One clone (AYH 8) cont
Integrated hepatitis B virus (HBV) DNA sequences were found in neoplastic liver tissue of a hepatitis B surface antigen (HBsAg)-negative child who had previously suffered from HBsAg-positive chronic active hepatitis and was anti-HBs and antihepatitis B core (HBc) positive at the time of tumor develo