To investigate the hepatitis B virus (HBV) DNA status in the liver when hepatocellular carcinoma (HCC) has developed, 35 paired nontumorous and tumorous liver tissues from 27 hepatitis B surface antigen (HBsAg)-seropositive and 8 HBsAg-negative patients with HCC were studied by Southern blot analysi
Hepatitis B Virus Core Protein Variations Differ in Tumor and Adjacent Nontumor Tissues from Patients with Hepatocellular Carcinoma
β Scribed by Zhu, Yu; Jin, Yan; Cai, Xiaojin; Bai, Xin; Chen, Min; Chen, Taoyang; Wang, Jinbing; Qian, Gengsun; Gu, Jianren; Li, Jinjun
- Book ID
- 111944212
- Publisher
- S. Karger AG
- Year
- 2012
- Tongue
- English
- Weight
- 273 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0300-5526
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## Abstract Few data are available on the levels of HBV DNA in liver tissue of patients with hepatocellular carcinoma. In this study, HBV DNA was quantitated by a TaqMan realβtime PCR method and results were normalised to an endogenous reference gene. The assay could detect reproducibly viral seque
## Abstract Hepatitis B virus (HBV) infection is closely associated with the development of hepatocellular carcinoma (HCC), but definite mechanisms by which it could play an etiologic role have not yet been identified. Modifications of the function of the RB tumor suppressor gene, which regulates t