In chronic hepatitis B virus (HBV) infection, mutations develop frequently at nucleotides 1,762/ 1,764 in the X protein open reading frame, where the core promoter is also located. By using a modified allele-specific polymerase chain reaction method, the longitudinal emergence of the AβT mutation at
β¦ LIBER β¦
Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage
β Scribed by M Lindh; P Horal; A P Dhillon; Y Furuta; G Norkrans
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 316 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0270-9139
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Spontaneous mutations of hepatitis B virus (HBV) could influence the severity of liver disease. Since the basal core promoter (BCP) and the precore (Pc) regions are important for viral replication, these regions were examined for naturally occurring mutations and were correlated with the genotype, e