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Hepatitis B virus C gene heterogeneity in a familial cluster of anti-HBc negative chronic carriers

โœ Scribed by G. Fiordalisi; D. Primi; E. Tanzi; E. Magni; C. Incarbone; A. R. Zanetti; E. Cariani

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
563 KB
Volume
42
Category
Article
ISSN
0146-6615

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โœฆ Synopsis

Abstract

We studied a familial cluster of adult HBV chronic carriers characterized by serological markers of active viral replication, normal or slightly elevated ALT levels and, in four out of five cases, absence of antiโ€HBc reactivity. The nucleotide sequence of the preโ€C/C region of HBV was analyzed in three patients, showing the presence of wildโ€type HBV sequences accompanied by different deleted molecules. Some of the variant genomes were able to encode proteins retaining HBcAg and/or HBeAg reactivity, whereas others contained deletions leading to the synthesis of truncated proteins that could not be immunoprecipitated by antiโ€HBc or antiโ€HBe monoโ€ and polyclonal antibodies. Defective molecules encoded by the variant C gene sequences might play a role in the determination of the clinical profile observed in the analyzed patients. ยฉ 1994 Wileyโ€Liss, Inc.

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