✦ LIBER ✦

Hepatitis B viral markers in severe viral hepatitis: Influence of steroid therapy

✍ Scribed by Harry B. Greenberg; William S. Robinson; C. Michael Knauer; Peter B. Gregory

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 386 KB
Volume: 1
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840010109

No coin nor oath required. For personal study only.

✦ Synopsis

In our double-blind randomized trial of methylprednisolone vs. placebo in severe viral hepatitis, 16 patients with hepatitis B (8 on steroid, 8 on placebo) were followed for at least 4 weeks. Four of the eight patients receiving methylprednisolone eventually died and all patients on placebo survived. Despite marked reduction in serum IgG in steroid-treated patients, the decline in HB.Ag titer and disappearance of Dane particle markers was the same in both treatment groups. A nonspecific depression of anti-HBc was noted in patients given steroid. There is no evidence that corticosteroid therapy accelerates viral replication when the acute hepatitis is severe.

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