๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Hepatitis B vaccine in the prevention of perinatally transmitted hepatitis B virus infection: Final report on a West Midlands pilot study

โœ Scribed by Dr. Susan M. Wheeley; Elizabeth H. Boxall; Michael J. Tarlow; A. Rashid Gatrad; Janet Anderson; Jeffrey Bissenden; Kwei Cheong Chin; Andrea Mayne


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
344 KB
Volume
30
Category
Article
ISSN
0146-6615

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โœฆ Synopsis


A four-dose vaccination schedule was used to interrupt perinatal transmission of hepatitis B virus from carrier mothers to their babies. Of 49 babies immunised and successfully followed up, 43 (88%) became immune: 15 out of 21 (71%) of babies born to HBeAg + mothers became immune, the other 6 becoming the only carrier babies in the study. Without immunisation a carrier rate in excess of 70% would have been expected in this high-risk group. Vaccine alone, given in a rapid immunisation schedule, protected the majority of babies at risk. In those babies in whom the carrier state occurred in spite of immunisation, infection may have taken place in utero, or the infant may have failed to produce adequate antibody in response to the vaccine.


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