✦ LIBER ✦
Hepatitis b surface antigen production as a growth cycle-related terminal event in plc/prf/5 hepatoma cells
✍ Scribed by Jennifer A. Copeland; Jacinta Skelly; George F. Mann; Colin R. Howard; Arie J. Zuckerman
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 685 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
The dynamics of hepatitis B surface antigen production by PLC/PRF/5 hepatoma cells were studied using a quantitative radioimmunoassay method. Maximum rates of antigen production were found in nutrient‐depleted, non‐dividing cultures and were temporally related to cytological changes preceding cell death. These results indicate that antigen production may be cell‐cycle related and represent a terminal event.