Important innovations, such as hepatitis B immune globulin (HBIG) and lamivudine, have been introduced to the care of patients undergoing liver transplantation (OLT) for viral hepatitis B (HBV) (over the last 15 years). We analyzed survival of OLT recipients with HBV in the United States to examine
Hepatitis B in the cambridge dialysis and transplant unit 1966–1983
✍ Scribed by J. Nagington; G. M. Sutehall; B. J. Cohen
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 464 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0146-6615
No coin nor oath required. For personal study only.
✦ Synopsis
The results of hepatitis B surveillance of the Cambridge dialysis and transplant units from June 1969 to July 1983 are reported. On admission 34/528 (6.44%) haemodialysis patients had anti-HBc. Preadmission screening excluded 19 HBs Ag carrier patients and two carrier staff. Eight patients became antigenaemic after admission and two others were found to be antigenaemic post-transplantation but pretransplant sera were not available from them. These two had active hepatitis and of the others, seven had asymptomatic carriage and one had acute hepatitis during haemodialysis. Two infected patients were admitted temporarily and one antigenaemic organ donor identified retrospectively. No cross infection occurred on the unit and the only instance of accidental infection of a member of staff was from an outpatient.
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Hepatitis B virus (HBV) recurrence following liver transplantation (LTx) has been controllable primarily with the use of hepatitis B immune globulin (HBIg) and lamivudine (LAM). However, HBV resistance to LAM and/or HBIg has become an increasing problem prompting the use of newer antiviral agents. T
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