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Hepatitis B immunization and hepatocellular carcinoma: The Gambia hepatitis Intervention Study

✍ Scribed by Ruggero Montesano

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 77 KB
Volume: 67
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.10093

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✦ Synopsis

Abstract

The Gambia Hepatitis Intervention Study (GHIS) was initiated by the International Agency for Research on Cancer (IARC) in 1986. It consisted of a randomized trial in the Gambian population, aiming to evaluate the protection provided by HBV vaccination administered during the first year of life against primary infection, the development of chronic carriage, and primary liver cancer. The results, reported at 9 years from the introduction of the vaccine as conferring a high degree of protection (83% against primary infection and 95% against chronic carriage), are briefly discussed. It is expected that HBV vaccination will result in a reduction of mortality from hepatocellular carcinoma, the most frequent cancer in males in sub‐Sahara Africa. J. Med. Virol. 67:444–446, 2002. © 2002 Wiley‐Liss, Inc.

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