𝔖 Bobbio Scriptorium
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Hepatitis A-virus in cell culture

✍ Scribed by J. Zahn; A. Vallbracht; B. Flehmig

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
396 KB
Volume
173
Category
Article
ISSN
0300-8584

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## Abstract Clinical isolates of hepatitis A virus (HAV) replicate inefficiently in cell culture unless mutations are acquired throughout the genome. An Ala‐to‐Val substitution in the nonstructural protein 2B (2B‐216) was known to have a major impact on replication in cell culture. Analysis of chim