Hepatitis A causing a second episode of virus–associated haemophagoeytic lymphohistiocytosis in a patient with Still's disease

✍ Scribed by J. R. McPeake; W. J. R. Hirst; A. M. Brind; Dr. Roger Williams

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 340 KB
• Volume: 39
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890390216

✦ Synopsis

A 20-year-old female with Still's disease who had contracted hepatitis A became critically ill 2 weeks after the onset of jaundice with pancytopenia, coagulopathy, deteriorating liver function tests, and hepatomegaly. The diagnosis of virus-associated haemophagocytic lymphohistiocytosis was made, and she improved slowly after supportive treatment with parenteral steroids and immunoglobulin. Twelve years earlier, a t the onset of her arthritis, she had suffered a similar episode of haemophagocytic lymphohistiocytosis in association with Epstein-Barr virus infection. 0 1993 Wiley-Liss, lnc.