Hepatic xenotransplantation will benefit from strategies aimed to reduce complement activation
✍ Scribed by P. Ramirez; J. Yelamos; P. Parrilla; R. Chavez
- Book ID
- 102468180
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 36 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1527-6465
No coin nor oath required. For personal study only.
✦ Synopsis
The hypothesis by Platt 1 that liver xenotransplantation in acute liver failure would not require manipulation of complement activation may look rather attractive because low complement levels seem to accompany this condition.
Platt's opinion supports the study by Tector et al, 2 which reported the absence of histological signs of hyperacute rejection in 2 porcine livers used for extracorporeal perfusion in 2 patients with liver failure (1 patient, primary biliary cirrhosis with terminal decompensation; 1 patient, fulminant hepatic failure of unknown cause). However, the following clinical and experimental evidence suggests that liver xenotransplantation will benefit from intervention on complement activation.